Failure of mebendazole to cure trichomonal vaginitis resistant to metronidazole: case reports.
نویسندگان
چکیده
After a recent report showing the in vitro susceptibility to mebendazole of a strain of Trichomonas vaginalis that was resistant to metronidazole, we present two cases of metronidazole resistant infection, both of which failed to respond to oral mebendazole.
منابع مشابه
Trichomonal vaginitis treated with one dose of metronidazole.
Since its introduction in France, metronidazole (Flagyl) has become the standard treatment for trichomonal vaginitis (Durel, Roiron, Siboulet, and Borel, 1959). The course recommended at that time and continued ever since was 200 mg. three times daily for 7 days, giving a cure rate of 85 to 98 per cent. (Csonka, 1963; Evans and Catterall, 1970; Keighley, 1971). We have investigated the possibil...
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The treatment of trichomonal infestations of the genito-urinary tracts of both men and women has been greatly improved since the introduction of metronidazole in 1959. Cure rates in women of over 80 per cent, have been reported by several observers (Rodin, King, Nicol, and Barrow, 1960; Nicol, Barrow, and Redmond, 1960; Watt and Jennison, 1962). Even higher cure rates have been claimed in cases...
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متن کاملMetronidazole-resistant Trichomonas vaginalis.
A 36-year-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 years had a total of 22 courses of treatment with either metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of Trichomonas vaginalis isolated from the patient was 160 microgram/ml compared with 1.25-10 microgram/ml for oth...
متن کاملNifuratel compared with metronidazole in the treatment of trichomonal vaginitis.
Nifuratel (Magmilor) was compared with metronidazole (Flagyl) in the treatment of trichomonal vaginitis by a randomized double-blind trial. Only 18 out of 47 patients (38%) treated with nifuratel were found to be cured, whereas 42 out of 49 patients (85%) treated with metronidazole were cured. Severe reactions, necessitating withdrawal of treatment, occurred in three patients treated with nifur...
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ورودعنوان ژورنال:
- Genitourinary medicine
دوره 65 4 شماره
صفحات -
تاریخ انتشار 1989